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The bicycle is approximately 200 years old. The past several decades have borne witness to a booming interest in recreational and competitive cycling. According to recent estimates, there are more than 70 million bike riders in the United States alone. This increasing participation in cycling deserves investigation of the potential traumatic and overuse injuries experienced by cyclists. Since 1975, there have been increasing numbers of published reports on the effect of bicycling on sexual function. In the present review, an overview of the relationship between bicycling and erectile dysfunction is presented. Proposed prevention and treatment strategies for erectile dysfunction among cyclists are reviewed.