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Club drugs such as 3,4-methylenedioxymethamphetamine (‘ecstasy’), methamphetamine (‘crystal meth’) and ketamine (‘Special K’) are becoming more and more popular. Many young adults take these designer drugs to enhance sensory experiences at ‘circuit parties’ and ‘raves’. Many users claim that these drugs also enhance sexual experience. However, many of these drugs have adverse effects on sexual function, as well as on sexual decision- making. This review examines four common club drugs, their systemic effects and their effects on sexual function, and hypothesizes on the causes of sexual dysfunction due to these drugs.