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Left main coronary artery disease is associated with poor clinical outcomes. Coronary artery bypass graft surgery has been the standard treatment for unprotected left main coronary artery disease. However, with the introduction of drug-eluting stents and advances in catheter techniques, together with advances in periprocedural adjunctive pharmacotherapies, percutaneous coronary intervention has become a viable alternative to coronary artery bypass graft for the management of this complex coronary lesion. The authors describe percutaneous coronary intervention in the treatment of unprotected left main coronary artery disease and briefly review its role in the management of patients with the condition.