CAHR Abstracts 2002

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BASIC SCIENCES / SCIENCES FONDAMENTALES
ORAL PRESENTATIONS / PRÉSENTATIONS ORALES

IMMUNOLOGY AND PATHOGENESIS

[101] LIGATION OF CXCR4 OR CCR5 ENHANCES SENSITIVITY OF CD4+ T CELLS TO TRAIL INDUCED APOPTOSIS
Julian J Lum
1, Zilin Nie1, Jaime Sanchez-Dardon1, David H Lynch1, Andrew D Badley1
1Ottawa Health Research Institute, Ottawa, Ontario; 2Immunex Corporation, Seattle, Washington

[102] GENITAL CHALLENGE FOLLOWING MUCOSAL IMMUNIZATION WITH INACTIVATED gp-120-DEPLETED HIV (REMUNE) PLUS CpG ODN
Nancy Dumais1, Janina Jiang1, Ronald B Moss2, Heather L Davis3, Kenneth L Rosenthal1

1Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario; 2Immune Response Corporation, Carlsbad, California; 3Coley Pharmaceutical Group, Ottawa, Ontario

[103]EPITOPE MAPPING OF HUMAN MONOCLONAL ANTIBODIES (mAB) TO HIV-1: AN INNOVATIVE METHOD TO DEVELOP NOVEL CANDIDATE VACCINES FOR HIV-1
Jillian LM Waruk1, Jody D Berry2, Keith Fowke1, Francis A Plummer1,3
1Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, Manitoba; 2National Centre for Foreign Animal Disese, Winnipeg, Manitoba; 3National Microbiology Laboratory, Winnipeg, Manitoba

[104] ROUTE OF EXPOSURE DOES NOT INFLUENCE THE PRESENCE, BREADTH OR MAGNITUDE OF HIV-SPECIFIC CTL RESPONSES IN EXPOSED UNINFECTED INDIVIDUALS
George Makedonas1, Julie Bruneau2, Rafik Sékaly 3, Michel Alary4, François Lamothe2, Catherine Lowndes5, Nicole F Bernard1
1Immune Deficiency Treatment Center, McGill University Health Centre Research Institute; 2Research Institute of the Centre Hospitalier de l’Université de Montreal; 3University of Montreal; 4Centre Hospitalier de l’Universite de Quebec, Montreal, Quebec; 5Department of Social Science and Medicine, Imperial College, London, United Kingdom

[105] REVERSIBLE ANERGY OF HIV-SPECIFIC CD4+ T-CELLS DETECTED BY CLASS II TETRAMERS
B Yassine Diab*1, G Breton1, S Younes1, N Bernard2, K MacDonald3, M Legault2, J-P Routy2, R-P Sekaly1
1University of Montreal, Quebec; 2McGill University Medical Centre, Montreal, Quebec; 3University of Toronto, Ontario

[106] PRESERVATION OF THE HIV SPECIFIC CD4+ RESPONSE IS ASSOCIATED WITH THE MAINTENANCE OF CD8+ HIV SPECIFIC RESPONSE
Galit Alter1, Christos M Tsoukas1, Roger P LeBlanc1, Eric Lefebvre2, Harold Dion2, Rafik-Pierre Sékaly3, Jean-Pierre Routy1, Nicole F Bernard1
1McGill University Health Centre, Montreal, Quebec; 2Clinique l’Actuel, Montreal, Quebec; 3University of Montreal, Montreal, Quebec

[107] AZT INHIBITS ANTIGEN-DRIVEN CLONAL EXPANSION OF T CELLS
Beni M Sahai1,3, P Bhutani1, AM Dar1,3, AB Gumel4, PN Shivakumar4
1Cadham Provincial Laboratory; 2Manitoba Institute of Cell Biology; Departments of 3Medical Microbiology and 4Mathematics, University of Manitoba, Winnipeg, Manitoba

[108] DEVELOPMENT OF SUSPENSION ARRAY ASSAY FOR THE QUANTITATIVE MEASUREMENT OF HIV-1 ANTIBODIES
S Faucher
, A Martel, M Bergeron, F Mandy
Health Canada, Centre for Infectious Disease Prevention and Control, National HIV Immunology Laboratory, Ottawa, Ontario