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PET AND RECOVERY FOLLOWING REVASCULARIZATION TRIAL (PARR-2): FDG PET-GUIDED THERAPY VERSUS STANDARD CARE IN SEVERE LV DYSFUNCTION
R Beanlands, G Nichol
The null hypothesis was that compared to standard care, PET-guided therapy was identically distributed with respect to the composite endpoint of cardiac death, MI, transplantation, or re-hospitalization for angina or heart failure. Secondary hypotheses evaluated QoL, costs, cardiac events, and EF. 430 patients were randomized to FDG PET-guided therapy (n=218) or standard care (n=212). One year RR for the composite endpoint was 0.84 (95% CI 0.63,1.1; p=0.25). This is the largest RCT to assess viability imaging. Patients in the FDG PET arm tended to have fewer cardiac events within 1 year. Longer-term follow-up is ongoing. Secondary endpoint analyses will also be presented.
Ottawa, Ontario