The drug discovery and development process in the new millennium
Remarkable changes are taking place within the world of pharmaceutical research and development (R&D). In the early 1900s, the discovery of a first generation of pharmaceuticals relied on chemistry and serendipity. Only relatively small molecules could be synthesized, and they were tested in vivo. Medicines were largely palliative, technology was relatively primitive, and the research process was manually based and labour intensive (Table 1).