Models for pharmacoeconomic analysis
TR Einarson | NH Shear | PI Oh
OBJECTIVE: To describe types of models currently available for use in economic analyses of drugs.
DATA SOURCES: Published economic analyses of drugs.
DATA SYNTHESIS: Three types of pharmacoeconomic models are prospective, retrospective and predictive. Prospective models are conducted as part of a randomized clinical trial. They are highly controlled but limited in extrapolation of results. Retrospective models involve chart reviews or database analysis. They represent a broad range of patients but lack controls. Predictive models are based on decision trees and represent the average patient. They rely on the literature or experts for inputs.
CONCLUSIONS: The three models have different strengths and weaknesses. Combining models provides additional strength and validity.