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https://www.pulsus.com/dentistry-case-report.htmlDentistry: Case Report
Euro Dentistry 2017
September 20-21, 2017
25
th
Euro Dentistry Congress
September 20-21, 2017 Dublin, Ireland
Patrick Babczyk, Dentistry: Case Report
Dental neural crest-derived progenitor cells as a better source for jawbone repair
Patrick Babczyk
Bonn-Rhine-Sieg University of Applied Science, Germany
T
he gold standard for cellular therapy in regenerative medicine is mesenchymal stem cells. However, for jawbone repair it would be
beneficial to use stem cells pre-committed towards the osteogenic lineage. We have shown recently that adult stem cells derived
from dental follicles are pre-committed towards the osteogenic lineage. However, the availability of these cells derived from wisdom
teeth is restricted to the youth of the donors. Therefore, we investigated another cell type, dental neural crest-derived progenitor
cells (dNC-PC), which might have a similar differentiation potential and can be found in adult teeth. Dental neural crest-derived
progenitor cells from the apical pad which can be found beneath the papilla of maxillary third teeth were isolated and characterized
for mesenchymal markers. Similar to dental follicle cells, dNC-PCs are pre-committed towards the osteogenic lineage since they are
no longer able to differentiate towards adipocytes, endothelial cells and smooth muscle cells. In addition the dNC-PCs differentiate
towards osteoblasts within two weeks which is faster and might even be stronger than the other mentioned cell types. All three tested
cell types show the same pattern for mesenchymal stem cell marker, although they are of different embryonic origin: both, dNC-PCs
and DFCs, are derived from the brachial arc whereas MSC are derived from somites during embryogenesis. Since dNC-PCs showed
the strongest and fastest osteogenic differentiation of the tested cell types, they might be a suitable alternative for dental follicle cells
in jawbone repair.