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Volume 3 Journal of Nursing Research and Practice Nursing and Heart 2019
April 22-23, 2019
Nursing Education and Evidence Based Practice Conference
Heart Conference
April 22-23, 2019 Dubai, UAE
World
4th International
&
The challenges in managing Heart Failure with preserved Ejection Fraction (HFpEF)
Samer Ellahham
Cleveland Clinic, UAE
Heart failure is a life‐threatening disease and addressing it should be considered a global health priority. Approximately half of all
patients with Heart Failure have preserved Ejection Fraction (HFpEF) and, as life expectancies continue to increase in western
societies, the prevalence of HFpEF will continue to grow. In contrast to Heart Failure with preserved Ejection Fraction (HFrEF), no
treatment has been proven in pivotal clinical trials to be effective for HFpEF, largely because of the pathophysiological heterogeneity
that exists within the broad spectrum of HFpEF. This syndrome was historically considered to be caused exclusively by left ventricular
diastolic dysfunction, but research has identified several other contributory factors, including limitations in left ventricular systolic
reserve, systemic and pulmonary vascular function, nitric oxide bioavailability, chronotropic reserve, right heart function, autonomic
tone, left atrial function, and peripheral impairments. Multiple individual mechanisms frequently coexist within the same patient
to cause symptomatic heart failure, but between patients with HFpEF the extent to which each component is operative can differ
widely, confounding treatment approaches. This lecture focuses on our current understanding of the pathophysiological mechanisms
underlying HFpEF, and how they might be mechanistically related to typical risk factors for HFpEF, including ageing, obesity, and
hypertension.
Biography
Samer Ellahham is a board-certified Internist, Cardiologist and Vascular Medicine Senior Consultant. He is a Fellow of the American College of Cardiology and
key member in heart failure and transplant, adult congenital and pediatric cardiology, cardio-oncology and peripheral vascular disease sections. He is the Eminent
Editor of The Journal of Cardiology & Cardiovascular Therapy. He has served as Chief Quality Officer for SKMC since 2009. His research includes innovation, digital
healthcare solutions, telemedicine, block chain, patient experience and engagement, lean six sigma, change management, innovation, safety, risk management,
KPI management, safe surgery, heart failure, molecular biology, genetics, cardiac imaging, sports and nutrition. He is a recognized world-leader in these fields.
Samer Ellahham, J Nursing Research and Practice, Volume 3
DOI: 10.4172/2632-251X-C3-008