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December 09-10, 2019 | Barcelona, Spain
Volume 02
Journal of Immune Disorders & Therapy
J Immune Disord Ther, Volume 02
World Immunology 2019 & Cancer Summit 2019
December 09-10, 2019
9th WORLD CONGRESS ON
IMMUNOLOGY AND CANCER
Correlation between apparent diffusion coefficient values in breast magnetic
resonance imaging and prognostic factors of breast invasive ductal carcinoma
Background: We wanted to examine whether the apparent diffusion coefficient values obtained by diffusion-weighted imaging
techniques could indicate an early prognostic assessment for patients with invasive ductal carcinoma and, therefore, influence the
treatment decision making.
Objectives: The main objective was to evaluate the correlation between the apparent diffusion coefficient values obtained by
diffusion-weighted imaging and the key prognostic factors in breast invasive ductal carcinoma. Secondary objectives were to analyze
the eventual correlations between magnetic resonance imaging findings and prognostic factors in breast cancer; and to perform a
comparison between results in 1.5 and 3.0 T scanners.
Methods: Breast magnetic resonance imaging with diffusion-weighted imaging sequence was performed on 100 patients, who were
proven histopathologically to have breast invasive ductal carcinoma. We compared the apparent diffusion coefficient values, obtained
previous to biopsy, with the main prognostic factors in breast cancer: tumor size, histologic grade, hormonal receptors, Ki67 index,
human epidermal growth factor receptor type 2, and axillary lymph node status. The Mann-Whitney U test and the Kruskal-Wallis
analysis were used to establish these correlations.
Results: The mean apparent diffusion coefficient value was inferior in the estrogen receptor-positive group than in the estrogen
receptor-negative group (1.04 vs 1.17 x10–3mm2/s, p=0.004). Higher histologic grade related to larger
tumor size (p=0.002).We found association between spiculatedmargins and positive axillary lymph node
status [OR=4.35 (1.49-12.71)]. There were no differences in apparent diffusion coefficient measurements
between 1.5 and 3.0T magnetic resonance imaging scanners (p=0.513).
Conclusions: Low apparent diffusion coefficient values are related with positive expression of estrogen
receptor. Larger tumors and spiculated margins are associated to worse prognosis. Rim enhancement
is more frequently observed in estrogen receptor-negative tumors. There are no differences in apparent
diffusion coefficient measurements between different magnetic resonance imaging scanners.
Biography
Ricardo is a Portuguese resident Medical Doctor at Hospital do Barlavento Algarvio in Portimão, Portugal. Studied Pharmaceutical Sciences
in the Faculty of Pharmacy (Porto University) in Portugal. Graduated in Medicine by the Universidad Europea de Madrid in Spain. During his
internship, he joined the Clinical Radiology Department in the Hospital Universitario Quirónsalud Madrid, in Spain, where he developed great
interest in breast pathology, namely diagnosis and treatment for breast cancer. Clinical Internship in the Hospital da Beneficiência Portuguesa
de São Paulo in 2015, during a period of 12 months, granted by the UniversidadeAnhembi Morumbi, São Paulo, Brazil. He published his work
about the “Correlation BetweenApparent Diffusion Coefficient Values in Breast Magnetic Resonance Imaging and Prognostic Factors of Breast
Invasive Ductal Carcinoma” under the supervision of Dr. Vicente Vega Martínez, Head of the Clinical Radiology Department. Article published
on July 2018 in the “Porto Biomedical Journal”. Received the CIMQ17 1st prize award on best investigational work in 2017, by the Faculty of
Medicine of Compostela University in Santiago de Compostela, Spain. He has a major research interest, taking part on several projects on
Molecular Research and Cancer Diagnosis and Treatment. Reviewer for several peer-reviewed journals, both national and internationally.
RicardoMoutinho Guilherme Alves Soares
Hospital Quirónsalud Madrid, Spain
Figure 1. A 38-year-old woman with
invasive ductal carcinoma in the upper
external quadrant of the left breast