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Volume 3 Current Research: Integrative Medicine Chronic Diseases 2018
July 16-17, 2018
Chronic Diseases
July 16-17, 2018 Berlin, Germany
2nd International Conference on
The possible involvement of Epstein-Barr virus in the etiology of leukemia in Sudanese patients
Haitham E Elawad1, Shamsoun K Kafi2, Ismail Abd Elrahman2, Salaheldein G Elzaki3, Abuelgasim Eljaili1, Mohammed E Ornasir1 and Mohammed Y Elamir 1
1Omdurman Islamic University, Sudan
2National Ribat University College of Medical Laboratories Sciences, Sudan
3Radiation and Isotope Centre Khartoum, Sudan
The research studies the etiology of leukemia. No single known cause for all of the different types of leukemia exists. Controversial
hypotheses was proposed suggesting the role of physical as well as chemical and even biological factors as being responsible for
leukemia incidents. The actual cause of leukemia which is a serious cancer in Sudan is still under scrutiny. We hypothesized that EBV
could be involved in the etiology of leukemia. We describe here the results of our attempt to find a possible link between leukemia
and EBV. It is generally accepted that the EBV is an important etiologic factor in various tumors. Virtually little was reported about
the relationship between EBV genes and leukemia. However, no full-length analysis of any sub-strain of EBV in Sudan area has been
reported. The main objective of this study is to assess the incidence and the significance of EBV in patients with leukemia disorder
using diagnostic parameters including cell morphology, immunologic markers and molecular investigations. Our findings provided
evidence of the involvement of EBV in patients with leukemia. The results suggested that EBV DNA genome encoding the non-
glycosylated membrane protein BNRF1 pl43 was observed in a significant proportion of patients with ALL. We could not exclude
a correlation between these viral infections and later leukemogenesis in childhood ALL in Sudan. Further investigation on the link
between maternal EBV reactivation and the development of ALL in offspring needs to be explored. Neither latent infection nor
congenital infection could be excluded.
Biography
Haitham E Elawad is currently an Assistant Professor of Microbiology and Immunology at Omdurman Islamic University, Faculty of Medical Laboratory. He has
been appointed as the Associate Editor of Journal of Blood Disorders, Symptoms and Treatments, Canada. He has served as an Associate Editor of Sudan Medical
Laboratory Journal (SMLJ). He has been appointed as Member in the Editorial Board of Allergy and Immunology Journal.
Haitham E Elawad et al, Curr Res Integr Med 2018, Volume 3
DOI: 10.4172/2529-797X-C1-002