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Page 42
Journal of Skin
September 18-20, 2017 SAN ANTONIO, TX, USA
World Dermatological Congress
Dermatology Congress 2017
Association between lipid profile and serum testosterone in patients with hirsutism disease
Sohail Waheed1, Abdus Sattar2, Muhammad Ahmad3, sadiq ullah4 and Tanveer Syed 5
1Combined Military hospital, Swat, Pakistan
2Khyber medical university, Peshawar, Pakistan
3Peshawar Medical College, Peshawar, Pakistan
4Khyber medical college, Peshawar, Pakistan
5Salford royal NHS foundation trust Manchester, United Kingdom
Background: Hirsutism is defined as the growth of thick, dark excessive terminal hairs on the androgen
dependant areas of human body including the upper lips, chin and mandibles.Hirsutism may either be idiopathic
or it may be caused by polycystic ovary syndrome, non-classic adrenal hyperplasia, adrenal or ovarian tumors.
Androgen excess is the cardinal phenomenon that leads to hirsutism. Women with polycystic ovary syndrome
(PCOS) shows an abnormal lipoprotein profile, which is characterized by raised concentrations of plasma
triglyceride, marginally elevated LDL-cholesterol, and reduced HDL- cholesterol.There is relationship between
lipid abnormalities and serum testosterone levels.Among the causes of hirsutism the relation is well established
in PCOS but there is limited data on other causes of hirsutism which suggest this relationship.
Objective: The aim of this study was”To establish relationship between lipid profile and serum testosterone in
patients with hirsutism.”
Methods: All female patients of reproductive age group 18-45 presenting with hirsutism and who gave consent
for this study were included while, the patients of known metabolic diseases like diabetes mellitus, hypertension
were excluded. Hundred female patients were included in the study. After approval from ethical committee of
Advance Study and Research Board (ASRB) Khyber Medical University, blood sample of hirsutism patients were
collected for serum testosterone and lipid profile analysis in laboratory at Combined Military Hospital Peshawar.
Serum lipids were analyzed on Selectra E automated chemistry analyzer using kits provided by Merck Pakistan.
Serum testosterone level was analyzed by a kit (Access Testosterone Assay) provided by Beckman Coulter, using
chemical luminescence technique. The data obtained was analyzed through SPSS version-16 software.
Results: A significant p (<0.05) and a positive correlation (r=0.316) of testosterone with total cholesterol and
positive correlation (r=0.303) of testosterone with LDL cholesterol, a non significant p (>0.05) and a positive
correlation (r=0.041) of testosterone with HDL cholesterol was observed. Where as a non significant p (>0.05)
and no correlation (r=0.00) of triglyceride with testosterone was seen.
Conclusions: This study concluded that serum testosterone relationship with lipid profile in hirsutism disease
shows significant relationship with total cholesterol. Subsequently, this study also elaborated serum testosterone
relationship with LDL cholesterol in hirsutism disease. A significant and positive correlation relationship was
found.This study concluded that in hirsutism disease when level of serum testosterone deviated from normal
point also brings deviation in total cholesterol and LDL cholesterol.
Limitations: To investigate each and every patient of hirsutism for its cause, was not possible due to lack of
resources and funds.