dermatology-congress-2017-posters-accepted-abstracts

7 / 14

Page 35
Journal of Skin
September 18-20, 2017 SAN ANTONIO, TX, USA
World Dermatological Congress
Dermatology Congress 2017
Man, folliculotropic mycosis fungoides: A case report
Ibrahim Nafee
Mansoura University, Egypt
A58 years old man presented with multiple skin lesions of 3 years duration with progressive course. The condition
started with itchy hyper-pigmented plaques on the back. examinations revealed multiple hyper-pigmented
plaques on the back and shoulders, and thighs. Our differential diagnosis included mycosis fungoides, leprosy,
sarcoidosis, and amyloidosis. skin biopsy was done and revealed dense infiltration of follicular epithelium and
dermis by small to medium sized lymphocytes. The lymphocytes have scanty cytoplasm, dark and cerebriform
hyperchromatic nuclei. Immunohistochemical study revealed positive staining with CD4 and negative staining
with CD20. Two year later, the patient developed nodules and plagues with discharging material on the scalp and
similar lesions on face and neck. biopsy was taken from scalp nodule and revealed similar findings to the previous
biopsy from the back but with more dense infiltration. It shows positive staining with CD3, mild staining with
CD8 and negative staining with CD20. Final diagnosis was folliculotropic mycosis Fungoides of trunk and scalp.
Investigations were within normal apart from thyroid nodule, enlarged cervical and axillary lymph nodes by
ultrasound with distorted shape and lost hilum. Pan CT was done and revealed multiple bilateral enlarged upper,
lower deep cervical lymph nodes and posterior triangle lymph nodes in which the largest measured about 14 X 6
mm. bilateral enlarged axillary lymph nodes with preserved criteria. no other organomegaly. thyroid function tests
were normal. Bone marrow biopsy revealed normocellular, normal myeloid, erythroid, lymphoid series, normal
megakaryocytes and free of abnormal cells. folliculotropic MF is a distinct variant of MF. It affects about 10%
of MF patients in head and neck region. folliculotropic infiltrates often with sparing of the epidermis. most cases
show mucinous degeneration of the hair follicles. traditionally designated as MF-associated follicular mucinosis.
the deep, follicular and perifollicular localization of the neoplastic infiltrates, makes them less accessible to
skin-directed therapies. clinical staging systems for MF are not very helpful in folliculotropic MF. One or a few
plaques on the face and scalp do not have stage IAdisease and should always be considered as having tumor stage
disease. Survival of patients with folliculotropic MF is similar to that of classic tumor stage MF.