4 / 21
Page 46
Notes:
Volume 1, Issue 1
Journal of General Dentistry
Euro Dental Market 2017
December 07-08, 2017
DENTAL MARKETING
December 07-08, 2017 | Madrid, Spain
27
th
Global Summit and Expo on
Ahlam H Majeed, Journal of General Dentistry 2017, 1:1
Immunohistochemical expression of actin and s100 in pleomorphic adenoma and mucoepidermoid
carcinoma
Ahlam H Majeed
University of Baghdad, Iraq
Background
:The aimof this study was to evaluate the expression of fibroblast growth factor-2 andHeparanase in salivary pleomorphic
adenoma, and to correlate the two studied markers with each other and with clinicopathological parameters including: age, sex,
tumor site and histopathological presentation.
Methods
: Sections of twenty five formalin-fixed paraffin embedded tissue blocks specimens of salivary pleomorphic adenoma were
immunostained using monoclonal antibodies (Fibroblast growth factor-2 and Heparanase) to assess their expression in this tumor.
Results
: The expression of fibroblast growth factor-2 and Heparanase were positive in all pleomorphic adenoma cases (100%). The
positive expression of fibroblast growth factor-2 was significantly correlated with histopathological presentation (p-value=0.032), but
it was non-significantly correlated with FGF-2 and other clinicopathological parameters (age, sex, tumor site). The positiveexpression
of Heparanse was non-significantly correlated with the histopathological presentation (p-value=0.088) as well as with other
clinicopathological parameters (age, sex, tumor site). Statistically significant correlation was found between the expressions of both
studied markers (p-value= 0.0005).
Conclusion
: The fibroblast growth factor-2 and Heparanase positive expression was noted in all cases of salivary pleomorphic
adenoma signifying that both fibroblast growth factor-2 and Heparanase might contribute in the biological behavior of pleomorphic
adenoma. The highly significant correlation found in the expression of both markers suggests their synergistic and cooperative role
in the tumorigenesis of pleomorphic adenoma.
Biography
Dr. Ahlam obtained her B.D.S and MSc degree from the college of dentistry of Baghdad. She was a junior teaching staff in periodontal. In 2004 she obtained
professor degree in oral diagnosis department. In 2002 she was the head of oral diagnosis department from July-2002 to October-2006 and in 2006 she was the
head of Promotion department. In 2015 she was the head of scientific committee in Baghdad College of dentistry. Now she is Professor in oral pathology in dental
college, Uruk University. She is a Member of Iraqi Diabetic Society. She has more than 45 publications in the field of oral and maxillofacial pathology.
Dr_ahlamhameed@yahoo.com