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Parkinson’s & Movement Disorders
November 11-12, 2019 | London, UK
7
th
International Conference on
Parkinson’s 2019
November 11-12, 2019
J Neurol Clin Neurosci . | Volume 3
Volume 3
Journal of Neurology and Clinical Neuroscience
Basal Ganglias
Jana Mrzilkova
Charles University, Czech Republic
T
he basal ganglia are responsible for motor control, motor learning, executive functions, behaviour and emotions.
DTI-based tractography allows us to visualise neural tracts and see specific connections to the cortex and other
structures in the brain. This will help us to better understand the function of the basal ganglia and see differences
between the sides of the brain. The aim of this study was to visualise neural tracts in basal ganglia in healthy
participants and to compare statistical parameters of neural tracts from left and right side of the brain to determine
laterality. Subject underwent MRI examinations on a 3TMR scanner (Siemens MagnetomTrio, Erlangen, Germany)
at IKEM (Institute of Clinical and Experimental Medicine). DTI data were reconstructed in DSI Studio software.
We selected to reconstruct neural tracts in the caudate nucleus, the putamen and the Globus pallidus. We chose to
study structures of the left hemisphere and right hemisphere separately for further analysis. Regions representing the
selected basal ganglia were loaded from a provided atlas (Harvard Oxford Sub) and afterwards manually corrected
according to its proper anatomical position specified by a neuroanatomist in all dimensions on T1 weighted images.
Fiber tracking was performed and reconstructed neural tracts were analysed. Following statistical parameters were
obtained: number of tracts, tract length, tract volume, quantitative anisotropy, generalised fractional anisotropy and
normalised quantitative anisotropy. We found laterality in the basal ganglia with higher statistical parameters in the
left side of the brain. These results indicate that the dominance of the left basal ganglia might be connected with
the patients being right-handed. Results of this study will be used as a preliminary study in further research of basal
ganglia for pathology (Parkinson disease).
Biography
Jana Mrzilkova is neuroanatomist working at the Institute of Anatomy, Third Faculty of Medicine in Charles University, Czechia. She is
focused on micro CT imaging of soft tissues, especially brain, vasculate and blood supply of visceral organs.
jana.mrzilkova@lf3.cuni.cz