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Parkinson’s & Movement Disorders
November 11-12, 2019 | London, UK
7
th
International Conference on
Parkinson’s 2019
November 11-12, 2019
J Neurol Clin Neurosci . | Volume 3
Volume 3
Journal of Neurology and Clinical Neuroscience
The role of malfunctional mitochondria in the development of Parkinson’s disease
Hari Pai
King’s College London, UK
StatementoftheProblem:
Parkinson’s’Diseaseisthesecondmostcommonneurodegenerativedisorderintheworld.Itis
thoughttooccurduetodegradationofdopaminergicneuronswithinthesubstantianigraparscompactaofthebasalganglia.
ThispaperelucidatesonatheorythatonepotentialreasonforParkinson’sdevelopingisduetoproblemswithmitochondria.
Methodology & Theoretical Orientation:
A literature review of 2 web databases (PubMed, Web of Science) yielded
the papers which were used in this review.
Findings:
Theproblemswithmitochondriaarethoughttocomebyavarietyoffactors.Factorsofferedinthispaperinclude
themutationorabsenceofparkinorPINK1genes.ThisalterationinparkinandPINK1leadstochangesinthemitochondria
which are present in the human body. These can lead to compromised complex activity and increased oxidative stress.
Increasedoxidative stress (via free radicals or reactiveoxygen species) can lead todeletionofmtDNA(withmitochondria
having its owngenome).The deletionofmtDNAis a problemas it is known tobe one of the factors leading toParkinson’s.
venkatesh_pai@kcl.ac.uk