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Journal of Neurology and Clinical Neuroscience | Volume: 03
8
th
International Conference on
NEUROLOGICAL DISORDERS,
CENTRAL NERVOUS SYSTEM AND STROKE
&
International Conference on
NEUROLOGY AND NEUROSURGERY
December 04-05, Dubai, UAE
Joint event on
J Neurol Clin Neurosci, Volume: 03
The role of malfunctional mitochondria in the development of Parkinson’s disease
Hari Pai
King’s College London, UK
Statement of the Problem
: Parkinson’s’ Disease is the
second most common neurodegenerative disorder in
the world. It is thought to occur due to degradation of
dopaminergic neurons within the substantia nigra pars
compacta of the basal ganglia. This paper elucidates on a
theory that one potential reason for Parkinson’s developing
is due to problems with mitochondria.
Methodology & Theoretical Orientation
: A literature
review of 2 web databases (PubMed, Web of Science)
yielded the papers which were used in this review.
Findings
: The problems with mitochondria are thought to
come by a variety of factors. Factors offered in this paper
include the mutation or absence of parkin or PINK1 genes.
This alteration in parkin and PINK1 leads to changes in the
mitochondria which are present in the human body. These
can lead to compromised complex activity and increased
oxidative stress. Increased oxidative stress (via free
radicals or reactive oxygen species) can lead to deletion of
mtDNA (with mitochondria having its own genome). The
deletion of mtDNA is a problem as it is known to be one of
the factors leading to Parkinson’s.
Biography
Hari Pai has completed his MSc in Clinical Neuroscience from King’s
College London and is currently under taking an MBBS in Medicine at
that same university. He has 2 publications and has presented multiple
posters at international conferences. He is the LSNeuron Rep for his
universities Neuroscience society and also the Vice-President of the
Clinical Academic Research Society at King’s.
e:
hari.venkatesh_pai@kcl.ac.uk