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Food Science 2019
November 11-12, 2019
Food Science and Technology
November 11-12, 2019 | London, UK
3
rd
International Conference on
Volume 3
Applied Food Science Journal
Appl Food Sci J. | Volume 3
A new understanding of Environmental damage to the skin and prevention by topical antioxidants
Karen E Burke
Icahn school of medicine at Mount Sinai, USA
T
his presentation reviews recent research which has given us new insights into the molecular biology of extrinsic
aging of the skin. Not only does UV (ultraviolet) irradiation directly cause photoaging of the skin, but also
environmental pollutants significantly damage exposed skin by several mechanisms. Exposure to the noxious gases
of air pollution with simultaneous exposure to UVA can act synergistically to accelerate photoaging and to initiate
skin cancer. Also, ozone generated from pollutants reacting with UV induces oxidative stress of the skin’s surface
via formation of lipid peroxidation products, with cascading consequences to deeper layers. Furthermore, new
studies have demonstrated that particulate matter (PM) pollutants can penetrate the skin trans epidermally and
through hair follicles to induce skin aging via the aryl hydrocarbon receptor (AHR), a recently discovered ligand-
activated transcription factor that regulates and protects keratinocytes, melanocytes, and fibroblasts. With this
understanding that extrinsic aging of the skin is not only due to photoaging, we realize the necessity of protection
beyond sunscreen. Fortunately, correctly formulated topical antioxidants can prevent damage inflicted by both
UV and environmental pollution. The stringent requirements to achieve stability, penetration, and activity of these
effective antioxidants will be described.