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Volume 3
August 5-6, 2019 | Singapore
CANCER RESEARCH AND PHARMACOLOGY
STRUCTURAL BIOCHEMISTRY, STEM CELLS AND MOLECULAR BIOLOGY
24
th
International Conference on
International Congress on
&
Cancer Research 2019 & Structural Biochemistry 2019
August 5-6, 2019
Journal of Cancer and Metastasis Research
Successful delivery of docetaxel to rat brain using experimentally developed
nanoliposome: A treatment strategy for brain tumor
Salman Mondal
Jadavpur University, India
I
n the field of neuroscience research, the treatment of brain cancer remains a challenge due to poor permeation of conventional
chemotherapeutic drugs across the blood–brain barrier (BBB). Docetaxel (DTX) is found to be very effective against glioma cell
in vitro
. However,
in vivo
passage of DTX through BBB is extremely difficult due to the physicochemical and pharmacological
characteristics of the drug. No existing formulation is successful in this aspect. Docetaxel is known to be effective against various
tumors, including brain glioma. Nanoliposomal formulation is a promising novel strategy for site-specific drug delivery, without
affecting normal tissues. In this study, effort was made to send DTX through blood–brain barrier (BBB) to brain to treat diseases
such as solid tumor of brain (glioma) by developing DTX-loaded nanoliposomes. Primarilydrug-excipients interaction was
evaluated by FTIR spectroscopy. The DTX-loaded nanoliposomes (L-DTX) were prepared by lipid layer hydration technique
and characterized physicochemically.
In vitro
cellc viability assay and cellular uptake in C6 glioma cells was investigated.
Further,
in vivo
plasma and brain pharmacokinetic study by LC-MS analysis was performed. FTIR data show that the selected
drug and excipients were chemically compatible. The vesicle size was less than 50nm with smooth surface. Drug released slowly
from L-DTX
in vitro
in a sustained manner. The pharmacokinetic data shows more extended action of DTX from L-DTX in
experimental rats than the free-drug and Taxotere. DTX from L-DTX enhanced 100% drug concentration in brain as compared
with Taxoterein 4 h. Thus, nanoliposomes as vehicle may be an encouraging strategy to treat glioma with DTX.
Biography
Salman Mondal has completed his masters in pharmacy (clinical pharmacy and pharmacy practice) from Department of Pharmaceutical
Technology, Jadavpur University, Kolkata, West Bengal, India. His project work on “ Prospective observational study to asses patients
profile with clostridium defficile colitis in ICU “ and project has been done with collaboration of AMRI Hospital, Kolkata, West Bengal,
India.
salmanmondal1@gmail.com