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Volume 3
August 5-6, 2019 | Singapore
CANCER RESEARCH AND PHARMACOLOGY
STRUCTURAL BIOCHEMISTRY, STEM CELLS AND MOLECULAR BIOLOGY
24
th
International Conference on
International Congress on
&
Cancer Research 2019 & Structural Biochemistry 2019
August 5-6, 2019
Journal of Cancer and Metastasis Research
Tamoxifen citrate loaded polymeric nanoparticles for enhanced breast cancer therapy
Angana Mondal
Jadavpur University, India
V
arious chemotherapeutic agents are used to treat the breast cancer.
The existing anticancer agents do not greatly differentiate between
the cancerous and normal cells, leading to systemic toxicity and adverse
effects. Drug permeation into the cancer cells from the conventional
formulation is very poor due to less distribution and quick elimination. The
extensive distribution and rapid elimination from targeted organs result in
a greater require¬ment of the drug by the tissue, which causes undesirable
toxicity. Polymeric nanoparticles play an important role in delivering such
kinds of chemotherapeutic agents in a controlled manner. Nanoparticles
make it possible to deliver the desired concentration of drug in the specific
site, thus minimizing the side effects and reducing the toxicity. Anumber of
novel formulations with Tamoxifen citrate loaded polylactide-co-glycolide
(PLGA) based nanoparticles (TNPs) were developed and characterized.
Their uptakes in Michigan Cancer Foundation-7 (MCF-7) breast cancer
cells were also investigated. Nanoparticles were prepared by a multiple emulsion solvent evaporation method. Drug-excipients
interaction, surface morphology, zeta potential and size distribution, cellular uptake were carried out . No chemical interaction
was observed between the drug and the selected excipients. TNPs had a smooth surface, and a nanosize range (250–380 nm)
with a negative surface charge. Sustained drug release pattern of the nanoparticles were internalized well in the cytoplasm by
the MCF-7 breast cancer cells on a concentration dependent manner. Drug loaded nanoparticles were found to be more cytotoxic
than the free drug. TNPs (NP-4) showed the highest drug loading and were taken up well by the MCF-7 breast cancer cell line
in
vitro
. Thus the formulation may be suitable for breast cancer treatment.
Biography
Angana Mondal has completed her masters in “Clinical Pharmacy & Pharmacy Practice” from Jadavpur University. Her thesis topic
entitled “A Prospective Observational Study To Compare The Effects Of Ropivacaine With Bupivacaine in Brachial Plexus Block”. She
has completed her thesis in collaboration with AMRI Hospitals, Kolkata, India.
anganamndl1994@gmail.com