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Volume 2

Journal of Microbiology and Biotechnology Reports

Microbial Biotechnology 2018

September 17-18, 2018

Microbial Biotechnology & Vaccine Design

September 17-18, 2018 Lisbon, Portugal



World Congress on

Bacteriophages for prevention and treatment of Salmonella infection in poultry

T Gabisonia, M Loladze, N Chakhunashvili, M Nadiradze, M Alibegashvili, N Tamarashvili, T Katamadze, T Kalandarishvili and T Eliava

G. Eliava Institute of Bacteriophage, Microbiology and Virology, Georgia

Enteric Salmonella infection is a global problemboth in human and animals and has been attributed to be the most important bacterial

etiology for enteric infections worldwide with massive outbreaks occurring in recent years. Food animals are the primary reservoir

for human non-typhoid Salmonella infections. Poultry products are considered one of the major sources of Salmonella infections. In

many cases multi-resistant bacteria infecting humans have been directly linked to resistant organisms in animals. Existence of such

pathogens is problematic because of possible transmission of antibiotic resistant bacteria from animals to humans through the food

supply. The development of alternative anti-microbial remedies has become one of the highest priorities of modern medicine and

biotechnology. One of such alternatives might be bacteriophages as a prospective biocontrol method against contaminations caused

by antimicrobial resistant pathogens. Main goal of this work is development of bacteriophage-based product that can be used to

control Salmonella contamination on farm level. For formulating polyvalent phage preparation 3 phages with wide, complementary,

not-fully-overlapping host ranges were selected. Salmonella phages Sal.phi13, Sal.phi18 and vB_Stm 21 were mixed in the proportion

1:1:1 and lytic activity and host specificity of each individual phage was compared with that of the phages cocktail. It was observed

that the phage cocktail possessed broader host specificity within

S. typhimurium

serotype than each of three phages alone. It was

found that the host specificity of Salmonella cocktail was noticeably wider than that of the individual Salmonella phages. Salmonella

phage cocktail was effective against 65 out of 66 (98%) tested Salmonella strains in

in vitro



T Gabisonia is the Head of the Laboratory of Applied Microbiology at the G. Eliava Institute of Bacteriophage, Microbiology and Virology, Georgia. He is author of

more than 30 scientific articles and has participated in many local and international scientific projects.

T Gabisonia et al., J Microbio and Biotech Rept 2018, Volume 2