Special Issue: Impact of Coronavirus on Cardiac patients
Coronavirus disease-2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2). This is a rapidly evolving global pandemic that has impacted more than two million people worldwide so far. Recent studies indicate that the invasion of the respiratory tract occurs through the angiotensin converting enzyme 2 receptor. Interestingly, these receptors are highly expressed by the heart, and are involved in cardiac function mediated by the renin-angiotensin system as well as in the development of systemic hypertension and diabetes mellitus. Clinical manifestations of COVID-19 are dominated by respiratory symptoms including fever, cough, and shortness of breath, with potential development into severe pneumonia. In a group of patients, the disease can cause severe cardiovascular complications such as acute myocardial injury, myocarditis, arrhythmias, and venous thromboembolism. In addition, patients with pre-existing cardiovascular disease, diabetes mellitus, and congestive heart failure might have an increased risk of death. Therefore, understanding the mechanisms involved in cardiovascular injury caused by SARS-CoV-2 is paramount for the development of effective treatments in patients with cardiac disease.
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