A replication study found an association between genetic variations and adolescents' blood pressure and body mass index.

Adiposity and Blood Pressure (BP) have a strong inverse relationship, which may be partially accounted for by genetic risk factors. In adolescents aged 12 years to 18 years, three nucleotide variations (rs16933812 (PAX5), rs7638110 (MRPS22), and rs9930333 (FTO)) were linked to systolic blood pressure (SBP) and body mass index (BMI). We made an effort to confirm these results using a sample of adolescents our age. At ages 13 years, 15 years, 17 years, and 24 years old, blood pressure and anthropometric markers were examined in a total of 713 adolescents. We investigated the relationships between these variations and BMI and SBP using linear mixed models. rs9930333 (FTO) was connected to body mass index in our data, but not to systolic blood pressure. Neither rs7638110 (MRPS22) nor rs16933812 (PAX5) were connected to the body’s systolic blood pressure, respectively. The disagreement between the research may be somewhat explained by variations in phenotypic definitions and genetic architecture among populations, although nucleotide variant selection in the initial study may have produced un-replicable false-positive results.