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The genus Diospyros is a rich source for napthols and naphthoquinones. During the study, we have chemically examined the roots of three unexplored species of Diospyros crumenata for their chemical profile and biological activities. The plant materials collected from Ramghat of India. On conventional extractions with organic solvents and sequential chromatography yielded seven naphthoquinone derivatives, habibone (1), 8’-Hydroxyisodiospyrin (2), diospyrin (3), 4-Hydroxy-5methoxy2- naphthaldehyde (4), 5-Hydroxy-4-methoxy-2-naphthaldehyde (5), 4-Hydroxy-3,5-dimethoxy-2-naphthaldehyde (6), and 2-Methyl anthraquinone (7). These isolates were characterized by spectral data (2D NMR, 1H-1H COSY and 13C-1H COSY). In addition, these compounds were evaluated for their potential to inhibit parasitic protozoa belonging to the genera Trypanosoma, Leishmania and Plasmodium using in vitro antiprotozoal assay and anthelmintic activity against adult earth worms, Pheritima posthuma. The study showed that the isolates enjoy significant anthelmintic and antiprotozoal activity and supports its use in folk medicine. Further, three isolates were incorporated into mouth dissolving tablets. The tablets were prepared by wet granulation technique using different ratios of binder, super disintegrant Florite R, sweeteners, Instacoat mango flavour. The developed tablets were evaluated for various quality control parameters like appearance, taste, weight variation, thickness, hardness, in vitro disintegration time and friability. Results indicated successful formulation of mouth dissolving tablets with pleasant taste and satisfactory mouth feel with optimum physicochemical properties. Anthelmintics or antihelminthics are a gathering of antiparasitic drugs that oust parasitic worms (helminths) and other inward parasites from the body by either staggering or murdering them and without making critical harm the host. They may likewise be called vermifuges (those that paralyze) or vermicides (those that slaughter). Anthelmintics are utilized to treat individuals who are tainted by helminths, a condition called helminthiasis. These medications are additionally used to treat tainted creatures. Pills containing anthelmintics are utilized in mass deworming efforts of school-matured youngsters in many creating countries. The medications of decision for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is and praziquantel. Antiprotozoal operators (ATC code: ATC P01) is a class of pharmaceuticals utilized in treatment of protozoan disease. Protozoans share little for all intents and purpose with one another (for instance, Entamoeba histolytica, a unikont eukaryotic creature, is all the more firmly identified with Homo sapiens, which has a place with the unikont phylogenetic gathering, than it is to Naegleria fowleri, a bikont eukaryotic living being) thus operators viable against one pathogen may not be powerful against another. They can be assembled by mechanism or by organism.Recent papers have likewise proposed the utilization of infections to treat diseases brought about by protozoa. The improvement of medications for the treatment of irresistible ailments was a significant focal point of early innovative work endeavors; in 1900 pneumonia, tuberculosis, and looseness of the bowels were the three driving reasons for death in the United States and mortality in the main year of life surpassed 10%. In 1911 arsphenamine, the primary engineered against infective medication, was created by Paul Ehrlich and scientist Alfred Bertheim of the Institute of Experimental Therapy in Berlin.