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Clinical Nephrology and Research

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Clear cell renal carcinoma: Mutations and prognosis

Author(s): Nelson Diez Calzadilla*

We study what immunohistochemical and genetic alterations of ccRCC (using MLPA) are associated with tumor prognosis and aggressiveness. An analytical study was done with 57 patients underwent radical and partial nephrectomy, where we found that CAIX and tumor size were associated with worse Fuhrman grade. Certain genetic mutations (CDKN2A, BRCA1 and 2, p53, APC, MDM2, WT1) were associated with worst prognosis and death.


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Google Scholar citation report
Citations : 35

Clinical Nephrology and Research received 35 citations as per Google Scholar report

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