Current Research: Cardiology

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Correlation between heart rate variability and myocardial perfusion scintigraphy

Author(s): Rodrigo Daminello Raimundo*, Patricia Alves Ribeiro Santoro, Pamela de Souza Santos, Victor Santoro, Vitor Engrácia Valenti, Tatiana Dias de Carvalho, Andrés Ricardo Pérez-Riera, Juliana Zangirolami Raimundo, Paulo Evaristo de Andrade and Luiz Carlos de Abreu

Introduction: The use of myocardial perfusion scintigraphy (MPS) associated with physical stress or pharmacological is a noninvasive method of great diagnostic value in coronary artery disease (CAD). To evaluate and study how the autonomic nervous system (ANS) adapts to the different stimuli in the control of the cardiac system, under normal or pathological physiological conditions, the heart rate variability analysis is commonly used. We hypothesize that a positive CPM result is associated with a worsening of the HRV parameter.

Objective: To correlate the results of heart rate variability (HRV) parameters with those of CPM.

Method: This cross-sectional study evaluated 40 individuals of both sexes between the ages of 20 and 80 years, with or without previous history of CAD, who were indicated to perform the examination according to the criteria of the cardiologist. The heart rate was collected from beat to beat during 12 minutes at rest. Next, the myocardial perfusion study was performed, with a two-day protocol. On the first day the images were taken at rest and the second day after the pharmacological or physical stress. The HRV index data were analyzed by a specific computer program and compared statistically with the MPC results.

Results: In the frequency domain, the analysis of the sympathetic-vagal balance in our study through the indices and joint action of the vagal and sympathetic components on the heart, with sympathetic predominance (LF) (results were 0.022, 0.018 and 0.021 comparing with the parameters of perfusion analysis SSS, SRS and SDR, respectively.

Conclusion: We did not verify correlation between the cardiac autonomic modulation by linear parameters of HRV, with the positive or negative result of MPS, in patients with or without previous diagnosis of ischemic heart disease.


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