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Concurrent contamination with two agents may contribute to an disease with similar signs causing a medical problem for the practitioner being examined. Dengue symptoms that resemble other conditions such as leptospirosis, influenza A, Salmonella Typhi, Japanese encephalitis, chikungunya, and malaria. Co-infection should also be taken into account when treating dengue or enteric fever cases with or Individuals living in infectious regions are at risk of developing such infections either concurrently or being superimposed over a persistent acute infection.This research was conducted to track Enteric fever, malaria, and dengue patients with co-seropositivity and to monitor the baseline Salmonella antibody titer of voluntary blood donors serving the region’s general population. The present research was performed in the microbiology section,, Davangere Medical College J.J.M. Of the 824 febrile patients diagnosed with a positive serological examination for either typhoid, dengue or malaria, 189 patients were found to be co-seropositive to either of the above-mentioned diseases when immunochromatography was used to check their serum, Dengue ELISA and malaria antigen.. A total of 189 patients showed a co-seropositivity of 22.90 per cent for any of the above mentioned diseases. Typhoid-Dengue was reported to be 6.67% in 9.83% Typhoid- Malaria and 0.48% in all three. Dengue- Co-seropositivity of malaria was recorded at 5.94%. In stable community the basal titer was estimated to be < 1:20. The co seropositivity rate in our study is 22.9% which poses a challenge in the diagnosis and treatment of such patients. As the gold standards culture and microscopy are time consuming and molecular diagnostic tools not a practical reality in many rural and developing primary health centers, simple, rapid and sensitive serological methods are being used as an alternative diagnostic tool in diagnosing atypical co infections which in some instance leads to overwhelming diagnosis of co infections and improper treatment.
