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Endocrine disrupting chemicals have gained interest in human physiopathology and more and more studies aimed to elucidate how these chemicals compounds affect system. A wonderful number of endocrine disrupting chemicals seem to be able to interfere with the physiology of hypothalamus-pituitary-gonadal axis; however, every endocrine axis isadditionally a target for each EDCs and their action isn’t limited to one axis or organ. Several compounds may additionally have a negative impact on energy metabolic homeostasis altering fat and promoting obesity, metabolic syndrome, and diabetes. Different mechanism are proposed to clarify these associations but their complexity together with the degree of occupational or environmental exposure, the low standardization of the studies, and thus the presence of confounding factors have prevented to see causal relationship between the endocrine disorders and exposure to specific toxicants up to now. This manuscript aims to review the state of art of scientific literature regarding the results of Endocrine Disrupting Chemicals (EDCs) on system.