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Hematology is known as the study of blood regarding health and disease which consists of issues with the red blood cells (RBCs), white blood cells (WBCs), platelets, lymph nodes, blood vessels, bone marrow, and the proteins involved in bleeding and clotting. As biomedical engineers, it is especially vital to understand the mechanics of blood components to avoid unwanted results from implantations such as heart valves. A comprehensive review on the biomechanics of blood is discussed in this chapter. We will also discuss that even though the human blood is a non-Newtonian fluid, depending on the circumstances it can be assumed to be a Newtonian fluid.