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Hemangiomas are the most common benign tumors of the liver. They are usually asymptomatic and require no specific treatment as they are mainly diagnosed incidentally. However, some hemangiomas may present with different symptoms depending on size and location. Many surgical options are used to treat symptomatic hemangiomas. We report a case of giant hepatic cavernous hemangioma (14 cm) in a 33-year-old woman, which presented with pruritus and jaundice. She underwent Mesohepatectomy (resection of segments 4, 5, and 8) which is uncommon complicated surgical technique to treat benign hepatic tumors.