44 2033180199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Pulsus Journal of Surgical Research

Sign up for email alert when new content gets added: Sign up

In randomised studies of cancer treatments, the evidence of a survival benefit was frequently unclear

Author(s): S. Lewis*

The goal of the study is to determine what percentage of statistically significant survival gains for cancer treatments that have been reported in randomised trials are also consistent with a clinically insignificant gain. This study, published in prestigious journals between 2009 and 2019, is a cross-sectional analysis of reports of randomised clinical trials of cancer therapies that showed a statistically significant improvement in overall survival. The hazard ratio (HR) and upper 95% confidence limit for overall survival served as the primary outcome measure. Given the probable toxicity of oncologic therapies, we reasoned that an absolute survival benefit of 1.9% implied by an HR of 0.95 and 3.8% implied by an HR of 0.90 can be regarded clinically inconsequential.


Full-Text | PDF
 
Google Scholar citation report
Citations : 163

Pulsus Journal of Surgical Research received 163 citations as per Google Scholar report

Pulsus Journal of Surgical Research peer review process verified at publons
pulsus-health-tech
Top