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We conducted a Cochrane style systematic review. on the search strategy included common search engines: Medline, Embase, Cochrane, and Google Scholar for only eligible clinical trials (randomized controlled trials, RCTs;) comparing IV over oral iron therapy, up to July 2019. The primary outcome was the effect of IVIT on the change of haemoglobin level. Secondary outcomes were the effects of IVIT compared to oral iron on ferritin level, mean corpuscular volume and adverse effects. Data was collected from each trial and where applicable meta-analysed using RevMan.