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Journal of Pure and Applied Mathematics

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Mobileular morphology digital circuits and mathematical modelling

Author(s): Finley Harris*

Application of systems biology principles using examples of neuronal dopamine signaling pathways. The model presented is based on two approaches: cell morphology electronic circuits and mathematical modeling. Transcription and phosphorylation of DARPP32 were modeled by analog circuits based on the well-known approach. Circuit applications have been shown to help receive signal vibrations similar to those described in real biological systems. This combination, on the one hand, offers the possibility of simplifying computations, and on the other hand, the possibility of showing the dynamics of these signal paths. Considering the expected effects of changes in calcium channel function, a mathematical model of system component interactions is proposed. The average frequency of calcium current oscillations due to the presence of dopamine in the presented model is 30 Hz, which is consistent with the literature, and the frequency of such oscillations is up to tens of Hz.


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Citations : 16

Journal of Pure and Applied Mathematics received 16 citations as per Google Scholar report

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