Cleft lip and/or palate (CL/P) are birth defects that affect especially the buccal cavity. The estimated prevalence of CL/P is of approximately 1 per 700 live births. Therefore, they represent the most common craniofacial malformations in humans [1].

With respect to the causes of CL/P, a complex multifactorial etiology that results from interaction between various genetic and environmental factors has been described in the literature [1,2].