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Breast cancer is the causes of female mortality across the world. Among Asian countries, Pakistan has the highest rate of breast cancer. NGS analysis of cancer provides a platform to identify the novel drugs for human breast cancer. The regulatory mechanisms of critical cancer-associated genes involved in the progression of tumors help us to develop future therapeutics. Human breast cancer shows a diversity of histological types of mammary tumors compared to other types of cancer. Hereditary breast cancer is due to an inherited mutation in the BRCA1 and BRCA2 genes. Comparative analysis of Next-generation sequencing (NGS) technologies offer higher throughput and lower per-base cost as compared to legacy approaches such as Sanger sequencing. Several laboratories have recently reported applying an NGS approach for diagnostic testing of mutations in the BRCA1/2 genes or can help us to scan the Pakistani population and we can save many lives.