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OBJECTIVE: To create awareness about antibiotic and rational use for effective post-operative surgical site infection prevention. Besides emphasis on preventive management. Surgical Site Infection (SSI) is one of the most common hospital acquired infections, and according to recent studies its incidence is estimated to approximate 10% for all surgical interventions. SSIs are associated with increased antimicrobials resistance, treatment costs, prolonged hospital stay and increased mortality. They can also cause disfiguring scars, which can be problematic, particularly for young adults. Comorbidities along with inappropriate debridement procedure, unhealthy hospital environment, habitual activity, immunosuppression, nutritional deficiency, hypersensitivity causes prolong would healing. Here the scenario of post-operative surgical site infection with challenges and management has been highlighted in 107 patients who come in emergency department in postsurgical procedure dressing purpose and those who admit in indoor patient department after operative procedure. RESULT: Nosocomial infection is more prone to indoor patients compare to emergency department patient. Prolong hospital staying exaggerated the gram positive and negative bacteria for initiating infection process.