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The present research article deals with the amide analogues prepared by available very well-known name reactions. The author have studied the name reactions like Beckmann rearrangement, Schmidt reaction, Passerine reaction, Willgerodt–Kindler reaction and UGI reaction, which involves preparation of amide linage containing compounds. The main purpose of article is to provide information on the development of novel amide derivatives to the scientific community. Doing so, it focuses on mechanisms of action and adverse events, and suggests measures to be implemented in the clinical practice according to bioethical principles.