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Objective: There are many evidences about relationship between eating behavior and drug addiction. A number of susceptibility loci that point to shared higher order genetic pathways underling addiction were found in genetic studies. This study assumed that a Genome-wide Association Study (GWAS) of food addiction would produce important enrichment in genes and pathways related to addiction. Methods: This study done among 314 women of European ancestry, by using a GWAS of food addiction, which is determined by the modified Yale Food Addiction Scale (mYFAS). Results for enrichment of Single Nucleotide Polymorphisms (SNPs) (n 5 44), genes (n 5 238), and pathways (n 5 11) involved in drug addiction were tested. Results: Two loci met GW-significance (P < 2.5 10 -8) with no obvious roles in eating behavior, they are mapping to 17q21.31 and 11q13.4. GW results were significantly enriched for gene members of the MAPK signaling pathway (P = 0.02). After adjustment for multiple testing, candidate SNP or gene for drug addiction was not linked with food addiction. Conclusions: Limited support was delivered for shared genetic underpinnings of drug addiction and food addiction, although the GWAS of mYFAS, need further investigation and follow up.
Journal of Pharmacology and Medicinal Chemistry received 18 citations as per Google Scholar report