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Cancer is a major public health problem. Although there is an impressive improving in the cancer treatment and discovering new therapy lead to reduce the mortality rate. However, the current therapies are associated with side-effects. Recently, many studies focusing on the anti-cancer effects of honey. The mechanism of the anti-cancer activity of honey is not fully understood yet. The possible combined mechanisms are due to its apoptotic and an Antioxidant Activities. A forty years man diagnosed with T-cell acute lymphoblastic leukemia, the lymphoblasts reduce from 54% to 0 % after used the honey therapy. Seventy years old women diagnosed with irregular hard left breast lump cancer. After one year of honey therapy only without any other treatment, the cells became unremarkable cells. In conclusion, honey could be considered as a natural cancer therapeutic agent with a much more cost-efficient way, therefor relieving the economic burden in the future.