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In many organs and tissues of adult animals, the balance between cell renewal and cell death is maintained. In the body, different types of mature cells have a specific lifespan, and with their death, new cells are formed by the proliferation and differentiation of stem cells. Under normal conditions, the production of new cells is regulated in such a way that it remains constant among a variety of cells. Sometimes it is thought that the cells created respond to natural growth control mechanisms only for a short time. These cells produce clones. They create a significant increase in the number and size of a tumor or neoplasm. The term cancer refers to a malignant tumor. In addition to uncontrolled growth, malignant tumors also show metastases. In this case, small groups of cancer cells are isolated from the tumor and transported by lymphatic or blood vessels to other tissues, where they continue to multiply. In this case, a primary tumor in one location can cause a secondary tumor in another location. Today, in general, conventional treatments have been used to control and solve the problem of cancer, among which we can mention chemotherapy, immunotherapy, targeted therapy, and so on. Traditional cancer treatments usually have a low survival rate due to tumor progression, resistance to treatment, and inability to treat the tumor. Bacterial therapies have unique mechanisms for treating cancer that are not available by standard methods. Bacteria can specifically target tumors, actively invade and search for tissue, and cause toxicity in a controlled manner. Over the past decade, Salmonella Clostridium and other genera have controlled tumor growth and survival in animal models.