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Epilepsy is a very common neurological disease in childhood, with a high prevalence of vitamin D deficiency. In pediatric epileptic population, treatment with antiepileptic drugs influence bone metabolism, reducing bone mass and levels of serum vitamin D. Vitamin D deficiency may cause rickets and osteomalacia, resulting in a higher fracture risk and an increased incidence of osteoporosis in adult life. Vitamin D monitoring and supplementation is important in the management of epileptic children on long-term antiepileptic drugs. There are a few studies in literature related to the effects of vitamin D supplementation in epileptic children, concluding that the effects in these children differ from that in healthy population. Most studies recommend the prescription of vitamin D supplementation; however there is still a debate regarding the optimal level of vitamin D supplementation and its exact impact on bone mineralization.