Opinion
Carotid artery wire injury model, a neutralising IL-11 antibody inhibits vascular hyperplasia
Author(s): Catherine Nichols*
In individuals with coronary artery disease (CAD) and peripheral artery disease (PAD), vascular restenosis is still a substantial issue (PAD). A key underlying disease is neointimal hyperplasia, which is characterised by post-procedure proliferation and migration of vascular smooth muscle cells (VSMCs). Interleukin 11 (IL-11) was examined in a mouse model of injury-related plaque formation. Apoe/ mice were fed a hyperlipidemic diet and had their right carotid wire injured. Anti-IL11 antibody (X203), IgG control antibody, or buffer were administered into mice. We used ultrasound to determine the thickness of the vessel wall and the rate of blood flow. When compared to control, X203 treatment reduced post-endothelial injury vessel wall thickness and injury-related plaque in mice with caro.. Read More»
DOI:
10.37532/pulcj.22.6(2).17-18
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