Research Article
Anti-diabetic effects of fungal polysaccharides extracted from pholiota adipose
Author(s): Xiao-yan Wang, Fang-fang Liu* and Hai-ying Bao
BACKGROUND: Pholiota adiposa is a valuable edible and medicinal fungus.
METHODS: In this study, we aimed to investigate the anti-diabetic effects of the polysaccharides extracted from Pholiota Adiposa (PAP) by the method of water extraction and alcohol precipitation on streptozotocin-induced diabetic ICR male mice. PAP was analyzed by LS-MS method. Relevant biochemical indicators were detected by ELISA assay, hematoxylin-eosin staining (H & E), Fasting Glucose Levels (FBG), Oral Glucose Tolerance Test (OGTT), tissue homogenate biochemical measurements, immunohistochemical staining and western blot.
RESULTS: The results revealed that the PAP is a neutral polysaccharide composed of d-fructose, d-mannose, dextrose anhydrate, d-xylose, trehalose, and galactose. And the PAP treatment groups exhibited a significant reduction in FBG levels, the HD group was about 10 m.. Read More»
DOI:
10.37532/ pulhhr.22.6(2).57-63
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