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Department of Cardiovascular Surgery, School of Medicine, Bozok University, Yozgat, Turkey


  • Original Article   
    The incidence of FVL and PT G20210A mutations in patients with idiopathic deep venous thrombosis
    Author(s): Meral Ekim* and Hasan Ekim

    Background: Factor V Leiden (FVL), prothrombin gene (PT G20210A), and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are known as molecular biomarkers to evaluate the predisposition of deep venous thrombosis (DVT). These hereditary risk factors affect the natural anticoagulant mechanisms and activate the coagulation mechanisms because of an imbalance between procoagulant and anticoagulant factors. Our study aimed to determine the prevalence of these mutations in Turkish patients presenting with idiopathic DVT. Methods: A total of 135 patients with idiopathic DVT admitted to our clinic were investigated for FVL, PT G20210A, and MTHFR (C677T, A1298C) gene mutations. Screening of polymorphisms was carried out by using SNaPshot® multiplex system (Applied Biosystems Inc.). Wild, heterozygous and homozygous genotypic distributions o.. Read More»
    DOI: 10.14303/1983-8905.1000053