Editorial Office, Journal of Kidney Treatment and Diagnosis, Windsor, Berkshire, England

Publications

• Review   
  New discoveries in the pathophysiology, genetics, and treatment of IgA nephropathy
  Author(s): Vivette D. Agati and Hidefumi Mimura*
  
  IgA nephropathy has made significant improvement in recent years. The successful identification of several genetic susceptibility loci, the development of the multi pathogenesis model, the adoption of the Oxford pathology scoring system, and the formalisation of the Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment recommendations are some of the significant new directions and most recent developments we highlight in this article. We concentrate on the most recent genetic discoveries that support the significant role of hereditary variables and provide an explanation for some of the geoethnic differences in illness risk. The majority of IgA nephropathy susceptibility loci identified so far encode proteins involved in the upkeep of the intestinal epithelial barrier and the immune system's reaction to mucosal infections. The coordinated pattern of interpopulation .. Read More»
  DOI: 10.37532/ puljktd.22.5(4).42-44.

  • Abstract
  • Full-Text
  • PDF