Perspective
Melatonin treatment modifies heat shock protein immunolocalization in the cerebral cortex of heat-stressed rats
Author(s): Pruto Walker*
Clinically heat stress causes indications of central nervous system dysfunction. Heat Shock Proteins (HSPs) act as molecular chaperones, preventing cell damage. Melatonin has both curative and preventative effects on heatstroke-induced organ failure. The purpose of this study was to see if melatonin might protect the cerebral cortex from heat stress-induced histological and HSP60 immunoexpression changes in adult male albino rats. Forty adult male albino rats were separated into three groups: I (control), II (3 days heat stressed), and III (3 days heat stressed) (3 days heat stressed with melatonin treatment). Blood samples were taken for oxidative stress and antioxidant analyses, and cerebral cortex tissues were processed to produce slices for light microscopy evaluation.
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DOI:
10.37532/pulhhr.22.6(3).74-75
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