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Haematopoiesis Online Journals

Haematopoiesis is that the process by which all mature blood cells are produced. It must balance enormous production needs (the average person produces over 500 billion corpuscles every day) with the necessity to control the quantity of every blood cell type within the circulation. In vertebrates, the overwhelming majority of hematopoiesis occurs within the bone marrow and comes from a limited number of hematopoietic stem cells that are multipotent and capable of intensive self-renewal. Hematopoietic stem cells create to differing kinds of blood cells, in lines called myeloid and lymphoid. Myeloid and lymphoid lineages both are involved in dendritic cell formation. Myeloid cells include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, and megakaryocytes to platelets. Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. In developing embryos, blood formation occurs in aggregates of blood cells in the yolk sac, called blood islands. As development progresses, blood formation occurs in the spleen, liver and lymph nodes. When bone marrow develops, it eventually assumes the task of forming most of the blood cells for the entire organism. Red and white blood cell production is regulated with great precision in healthy humans, and the production of leukocytes is rapidly increased during infection.

 

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