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Journal of Cancer & Metastasis Research

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Bioinsilico analysis of c-MYC gene association with Burkitt’s Lymphoma

Joint Event on 24th International Conference on CANCER RESEARCH AND PHARMACOLOGY & International Congress on STRUCTURAL BIOCHEMISTRY, STEM CELLS AND MOLECULAR BIOLOGY

August 5-6, 2019 | Singapore

Enas Abdalla Mohammed Ahmedon

University of Khartoum, Sudan

ScientificTracks Abstracts: J Can Res Metastasis

Abstract :

Background: MYC gene is an important proto-oncogene transcriptional factor encodes a nuclear phosphoprotein for central cellular processes. Dysregulated expression or function of c-MYC is one of the most common abnormalities in human malignancies. The normal c-MYC gene is encoded in three separate exons divided by two large intervening sequences in this study we focused on detection of single nucleotide polymorphisms SNPs in MYC gene associated with formation of Burkitt’s lymphoma, and to confirm or exclude most reported SNPs relationship with the disease, and detect novel mutations associated with the disorder.

Materials and methods: MYC gene was investigated in NCBI database http://www.ncbi.nlm.nih.gov/) and SNPs were analysed by computational softwares. SNPs in the coding region (exonal SNPs) that are non-synonymous (nsSNP) were analysed by (sift, polyphen2, I-mutant, SNPs&GO and PHD-SNP softwares.

Result: we analysed 2868 SNPs from(NCBI) 286 of them found in Homo sapiens,48 of them deleterious furtherly investigated.

Conclusion: eight SNPs were considered most disease causing (rs4645959, rs4645959, rs141095253, rs141095253, rs150308400, rs150308400, rs150308400, rs150308400) according to the four softwares used. Two ofwhich have not been reported previously[rs4645959 (N25S), rs141095253 (P396L)].

Biography :

Enas Abdalla Mohammed Ahmedon is a student. Currently pursuing her master’s in University of Khartoum, Sudan and she is interested in hematology and immunohematology. She is good learner, interested in knowing, learning and developing skills, knowledge and competencies. And she works as Scientist at Jafar IBin Auf Specialized Hospital for Children – Khartou.

E-mail: [email protected]

 
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Citations : 8

Journal of Cancer & Metastasis Research received 8 citations as per Google Scholar report

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