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Aween Auda Ablahad, Hashim Dawood Mousa, Jalal Ali Jalal
University of Duhok, Iraq Hawler Medical University, Erbil, Iraq
ScientificTracks Abstracts: Dentist Case Rep
Introduction: Implication of Human Papilloma Virus (HPV) in the carcinogenesis of Oral Squamous Cell Carcinoma (OSCC) is debatable subject, p16 overexpression indicates active HPV infection in Oropharyngeal Squamous Cell Carcinoma (OPSCC) but in OSCC such relation still needs to be studied. Therefore, we aimed to evaluate the frequency of HPV in OSCC patients in the capital of Kurdistan region of Iraq and its concordance with p16 overexpression. We retrieved Eighty-six Formalin-Fixed Paraffin-Embedded (FFPE) samples of OSCC from multi large pathological centers that located in the capital of Kurdistan, we utilized Immunohistochemistry (IHC) to detect the HPV by anti-HPV high risk antibody correlated it with p16 overexpression, besides, twenty FFPE samples of healthy gingiva were used as control in this study. Chi square and Fisher’s exact tests were used for correlating the HPV status and p16 overexpression with clinic pathogical patient’s data. The concordance between HPV and p16 overexpression was evaluated by kappa agreement and spearman rank correlation. The frequency of HPV in OSCC patients were 15.1%, tongue was the most common site affected by HPV infection, other patient data including age, gender, grade and stage did not show significant correlation with neither anti-HPV nor P16 antibodies. The concordance level between p16 overexpression and the HPV status according to kappa agreement was (κ = 0.221, p= 0.034), Moreover, the correlation according to spearman correlation coefficient was (r = 0.229, p= 0.034), with 46.15% sensitivity and 80.82% specificity. We concluded that HPV infection is still low in Erbil and p16 biomarker has only diminutive significance as a predictor of HPV infection in the OSCC patients. Recent Publications 1. Benzerdjeb N, Tantot J, Blanchet C, Philouze P, Mekki Y, Lopez J, Devouassoux‐Shisheboran M (2021). Oropharyngeal squamous cell carcinoma: p16/p53 immunohistochemistry as a strong predictor of HPV tumour status. Histopathology.79(3):381-90. 2. de C. Ferreira C, Dufloth R, de Carvalho AC, Reis RM, Santana I, Carvalho RS, Gama RR (2021). Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma. Plos one. 16(6): e0253418. 3. Jiromaru R, Yamamoto H, Yasumatsu R, Hongo T, Nozaki Y, Nakano T, Hashimoto K, Nakagawa T, Oda Y (2021). p16 overexpression and Rb loss correlate with high‐risk HPV infection in oropharyngeal squamous cell carcinoma. Histopathology. 79(3):358-69.
Aween Auda Ablahad is a dentist and oral and maxillofacial pathology specialist, graduated from University of Mosul in 2009 with a bachelor degree. She earned her master degree in oral and maxillofacial pathology from college of dentistry/Hawler Medical University in 2016 and now she is a PhD candidate in the same specialty, she has her own private dental clinic since 2013. She is a lecturer and a member in college of dentistry, University of Duhok, Iraq.
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