Thirty years of standalone percutaneous coronary interventions: A 23,261 case experience from a Canadian tertiary referral centre
- *Corresponding Author:
- Dr William KK Hui
6th Floor, C K Hui Heart Centre, Robbins Pavilion, Royal Alexandra Hospital, 10240 Kingsway Avenue, Edmonton, Alberta T5H 3V9
E-mail: [email protected]
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Background: When percutaneous coronary intervention (PCI) was first performed >35 years ago, on-site cardiac surgery backup for PCI failure was deemed essential. As techniques improved and primary PCI became the preferred reperfusion strategy for acute myocardial infarction, many standalone PCI programs originally established to facilitate access to primary PCI started to perform elective PCI, which remains a Class IIb recommendation in American College of Cardiology Foundation/American Heart Association/Society for Cardiac Angiography and Interventions guidelines. Two recent United States studies showed that outcomes of elective PCI in standalone centres were noninferior to those with on-site cardiac surgery. The Royal Alexandra Hospital in Edmonton (Alberta) performed the first standalone PCI in Canada in 1981.
Objectives: The authors describe their first 30 years’ experience with PCI – the largest single-centre standalone experience reported to date.
Methods: Patient and procedural data have been collected since the first standalone PCI in 1981, evolving from paper records to a computer database and, in 1995, a provincial database. Quality assurance and peer review in collaboration with the regional cardiac surgery program was established from the outset.
Results: The success, emergency coronary bypass and death rates for 23,261 standalone PCIs performed between 1981 and 2011 were 96.0%, 0.2% and 0.5%, respectively. For 9068 PCIs performed between 2007 and 2011 (a period that most reflects contemporary practice), the rates were 96.5%, 0.04% and 0.6%, respectively. These results compare favourably with PCI results reported in literature, irrespective of the presence or absence of on-site cardiac surgery.
Conclusions: With high volumes and an experienced team, standalone PCIs can be performed safely with excellent success and low complication rates.
Cardiac surgery backup; Coronary revascularization; Standalone percutaneous coronary intervention
Percutaneous coronary intervention (PCI) is currently the predominant form of coronary revascularization. In the United States, 63.3% of 553,159 coronary revascularization procedures in 2009 were percutaneous interventions . In stable coronary disease, PCI improves symptoms of angina [2,3]. In acute coronary syndromes, timely restoration of normal coronary flow improves survival [4,5]. Primary PCI has become the treatment of choice for acute ST elevation myocardial infarction (STEMI) [6,7]. Better outcomes with shorter call-to-balloon times have prompted a significant number of ‘diagnostic angiography only’ centres to commence PCI programs without on-site cardiac surgery backup, ie, standalone PCI programs [ 8]. Although standalone PCI has many advantages in terms of logistic and economic considerations, some concerns remain as to the safety of such practice [9-12].
Nonetheless, new standalone PCI programs continue to be established worldwide with high procedural success and no apparent excess mortality or need for emergency coronary artery bypass grafting (CABG) compared with centres with on-site surgery [ 13-20]. The latest American College of Cardiology Foundation (ACCF)/American Heart Association (AHA)/Society for Cardiac Angiography and Interventions (SCAI) Guideline on Percutaneous Coronary Intervention, published in 2011 , supported and upgraded standalone PCI for STEMI from Class IIb to Class IIa recommendation. However, caution remained with regard to elective PCI, despite having also been upgraded from Class III to Class IIb recommendation [ 21]. More recently, Canadian researchers performed a meta-analysis of >100,000 primary and >900,000 nonprimary PCIs, comparing outcomes in standalone PCI centres versus those with on-site cardiac surgery, and found no increased risk for in-hospital mortality or early coronary bypass rates in standalone PCI centres [ 22]. The US Cardiovascular Patient Outcomes Research Team (CPORT-E)  and Percutaneous Coronary Intervention (PCI) Outcomes in Community Versus Tertiary Settings (MASS COMM) [ 24] trials also showed that outcomes of nonemergency PCIs performed in hospitals without on-site cardiac surgery were noninferior to that performed in hospitals with on-site surgery, although highrisk patients were excluded in both trials.
The Royal Alexandra Hospital in Edmonton, Alberta, performed the first standalone coronary angioplasty in Canada in July 1981. Our first 10 years of standalone PCI experience in 762 patients has previously been reported . In the present article, we describe our first 30 years’ experience with 23,261 cases, which we believe is the largest single-centre, standalone PCI experience reported to date.
PCI program structure
The Royal Alexandra Hospital is one of two tertiary care hospitals in Edmonton, with >900 beds. It is a major referral centre for patients from central and northern Alberta, adjacent provinces and the Northwest Territories beyond the Arctic circle. Regional and interprovincial patient services utilize ground ambulance, helicopters as well as fixedwing air ambulance for transport of patients to the facility. A cardiac catheterization and angiography program was set up in collaboration with diagnostic imaging in the 1960s. In the late 1970s, the first cardiac catheter laboratory was established and a second laboratory was added in 1999. A new heart centre with state-of-the-art facilities and equipment opened in 2011.
The centre was one of the first to demonstrate the safety of outpatient cardiac catheterizations  and, in Canada, one of the first to adopt coronary angioplasty as a technique for coronary revascularization early in its development, supported by the regional cardiac surgery program at the University of Alberta Hospital 6 km away (approximately 15 min door-to-door), with an operating room (OR) on standby while the procedure was performed at the site. Due diligence with the transfer process for PCI patients who required urgent CABG, including pilot runs to confirm logistics and feasibility of patient transport with intra-aortic balloon support, were performed before the first coronary angioplasty in July 1981.
Balloon angioplasty was the only PCI technique available in the first 12 years of the program. The first coronary stent was implanted in 1993. Glycoprotein IIb/IIIa inhibitors were introduced in 1997 and drug eluting stents in 2002. A radial PCI program started in 1999 and is now used in >80% of cases. Ancillary interventional techniques, such as intravascular ultrasound, fractional flow reserve, thrombectomy/distal protection and rotational atherectomy have all become an integral part of the program. Intra-aortic balloon pump has been available since 1984 and Impella (Abiomed, USA) circulatory support since 2008. A mitral valvuloplasty program was started in 1988 and septal ablation program for hypertrophic cardiomyopathy in 2005. A chronic total occlusion PCI program was started in 2010. An interventional cardiology fellowship program was established in 1991 and has trained >20 cardiologists from Australia, England, China, Hong Kong, Netherlands, Saudi Arabia, Singapore, Sweden, Thailand and Wales.
Initially, all potential PCI cases were reviewed weekly at a meeting attended by interventional cardiologists and cardiac surgeons. By the 1990s, as PCI volumes grew and more ad hoc PCIs were performed, separate weekly PCI and surgical case review meetings were held. PCI review included all emergency cases, complications and choice of revascularization and PCI approach in complex cases. As case volumes increased, uncomplicated emergency cases were not reviewed. Weekly meetings with cardiac surgeons included review of surgical cases as well as cases suitable for either percutaneous or surgical approach. Surgical backup was initially provided on an OR standby basis and, subsequently, on a next available OR basis since the early 1990s.
Since the start of the PCI program in July 1981, comprehensive data regarding indication, procedural success, complications, mortality and need for emergency CABG surgery were collected. In the first 10 years, only paper records were kept and archived for quality assurance. Since 1991, records have been kept in dBASE format and, from 1995 onward, these were kept in parallel with a new provincial database – Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) (27) until 2002. Since 2002, all records have been kept exclusively in the APPROACH database.
Medical records for all cases requiring cardiac surgery within 24 h of PCI were reviewed to confirm the timing of surgery, indication and operative outcomes. All deaths within 24 h of PCI, including all primary/rescue PCIs and patients in cardiogenic shock, were crossreferenced with hospital and regional health records. Patient survival was tracked by the APPROACH database through a linkage to provincial vital statistics.
From 1981 to 2011, 23,261 PCIs were performed. The results of the standalone PCI experience over four time periods, 1981 to 1991, 1992 to 2001, 2002 to 2006, and 2007 to 2011, are shown in Table 1.
|Ad hoc PCIs, %||n/a||62.6||75.4||85.5||76.1|
|Canadian Cardivascular Society class IV, %||n/a||60.8||67.0||69.1||66.2|
|Primary/rescue PCI, %||n/a||7.0||18.1||15.2||14.0|
|Stent use (since 1993), %||n/a||70.4||91.3||93.0||82.3|
|Procedural success, %||73.1||94.8||96.2||96.5||96.0|
|Emergency CABG, n (%)||12||(1.6)||20 (0.3)||6||(0.1)||4||(0.04)||42||(0.2)|
|Death within 24 h, n (%)||7||(0.9)||35 (0.6)||27||(0.4)||56||(0.6)||125||(0.5)|
CABG Coronary artery bypass grafting; n/a Data not available
Table 1: Royal Alexandra Hospital (Edmonton, Alberta) percutaneous coronary intervention (PCI) results, 1981 to 2011
Volumes of ad-hoc PCI and primary/rescue PCI for STEMI steadily increased. The last five-year period has had the greatest percentage of patients with Canadian Cardiovascular Society (CCS) Class IV angina. Lesion complexity was high. An annual audit in 2002 revealed that of 1573 lesions treated, 1098 (70%) were anatomically complex, classified as ACC/AHA B2 or C (10). This compared with 58.2% in 1996 and 18.6% in 1990 to 1991.
The PCI volume has exceeded 1100 per year since 2000 and 1500 per year since 2004. In parallel, the interventional cardiologist average case volume also increased from 170 PCIs per year in 1992 to 1996, to ≥250 PCIs per year since 2002.
The period from 2007 to 2011 most reflected contemporary practice and represented almost 40% of the total PCIs performed over the 30-year period. Of 9068 PCI cases performed, 1384 (15.3%) were primary/ rescue PCI for acute myocardial infarction, of which 354 (3.9%) were hemodynamically unstable. There were 4857 (53.6%) urgent inpatients with acute coronary syndrome and 2473 (27.3%) urgent outpatient cases. Only 354 (3.9%) cases were classified as low risk.
Procedural success was achieved in 96.5%. PCI was performed on an ad hoc basis in 85.5% of cases. Emergency CABG surgery was required in four patients (0.04%), three due to PCI failure and, in one unstable patient, PCI was performed on a severe left main lesion as a bridge to surgery after discussion with the cardiac surgeon on-call. Mortality rate at 24 h was 0.6%.
At 30 days, the mortality rate was 1.1%. CABG was performed in 42 (0.5%) patients and repeat PCI was performed in 510 (5.6%), of whom 431 (4.7%) were planned PCIs for nonculprit lesions and 79 (0.9%) were unplanned – 39 for subacute stent thrombosis and 40 for residual nonculprit lesion ischemia.
Since Andreas Gruntzig performed the first balloon coronary angioplasty in 1977 , the management of coronary disease changed forever. In the early years, acute coronary occlusion was the major complication limiting widespread application of this procedure. Our hospital had already performed coronary angioplasty for seven years by the time the first AHA/ACC coronary angioplasty guidelines were published in 1988, and subsequently updated in 1993, which recommended that angioplasty should not be performed without on-site cardiac surgery support [9,10]. Our first 10-year experience of standalone PCI (published in 1992 ) showed results comparable with then published benchmarks from centres with on-site cardiac surgery. However, our article was accompanied by two editorials, one of which questioned how our “approach ... will serve a useful role in interventional cardiology of the 1990s” , and the other concluded that “angioplasty should not be performed without on-site surgery facilities” .
Nonetheless, our OR standby for angioplasty in the 1980s gave way to the “next available OR” model in the early 1990s because infrequent use made OR standby costly and impractical. Similar to experience reported elsewhere [31-33], coronary stents and adjunctive antiplatelet therapy greatly improved our success rate and reduced the incidence of death and emergency CABG in the 1990s.
In the past 15 years, reports from Israel , Norway , Sweden [ 19] and Tasmania (Australia) , as well as from rural and metropolitan centres in the United States [13-16], have shown that standalone PCI is safe and has comparable outcomes with centres with on-site cardiac surgery. A survey conducted by the SCAI in 2007  reported that standalone PCI was practiced in >90% of responding countries. The British Cardiovascular Intervention Society 2013 audit of PCI procedures  showed that standalone PCI centres have now significantly outnumbered those with on-site cardiac surgery (69 versus 48), with emergency CABG surgery rate <1% .
The marked improvement in the safety of coronary angioplasty, together with emerging evidence in support of primary PCI as the preferred treatment for STEMI, led to a change in the ACC/AHA guidelines for standalone primary PCI from a Class III recommendation in 1993  to Class IIb in 2001 , and Class IIa in 2011 [ 21]. In the United States, standalone PCI programs have become a necessity to provide primary PCI in rural areas , and to provide elective PCI in diagnostic catheter laboratories in metropolitan areas with experienced cardiologists and personnel from tertiary centres [ 14-16]. The very low risk of standalone PCI-related complications was considered to be justifiable, in the rural setting when balanced against potential delays in reperfusion in STEMI patients, and in the metropolitan setting against the costs as well as logistics involved in same-day transfer or second procedure scheduling for PCI in centres with on-site surgery. A 2009 report from the National Cardiovascular Data Registry  showed that standalone PCI centres had similar procedural success, morbidity, emergency surgery and risk-adjusted mortality rates compared with on-site surgery PCI centres, whether in primary PCI or less-urgent nonprimary settings. In 2011, the ACC/ AHA/SCAI guidelines standalone elective PCI was upgraded from a Class III (no benefit/harm) to a Class IIb (benefit ≥ risk, may be considered) recommendation. The safety of elective standalone PCI was further substantiated by CPORT-E  and MASS COMM  studies in 2012 and 2013, respectively.
Over the past 30 years, our program has built an experienced team of interventional cardiologists, nurses and technologists, with established protocols and quality assurance programs. It is well documented that higher operator and hospital volumes are associated with better patient outcomes [36-38]. Our PCI volume rose from 762 cases in the first decade through 5909 cases in the second decade to 16,590 cases in the third decade of our experience. Our interventional cardiologist annual case exceeded both current United States and United Kingdom (UK) guidelines [21,39]. The broad experience of our interventional team is pivotal to success in complex cases, and to expedient and effective management of acute complications and emergencies. The comprehensive inventory of equipment that supports our case volumes also ensures that catheters, wires, balloons, stents and other new technologies essential for success are available when required. For 2007 to 2011, our procedural success, emergency CABG and death rates for a patient population of which 69.1% had CCS Class 4 symptoms and 15.2% required primary/rescue PCI, were comparable if not better than contemporary results reported worldwide [ 19,20,23,24,35,40], some of which excluded emergency and primary PCI patients (Table 2).
|Study (reference)||Procedures, n||Primary PCI, %||Lesion success, %||Emergency CABG, %||30-day mortality, %|
|RAH (2007 to 2011)||9068||15.3||96.5||0.04||1.1|
|Scotland (1997 to 2003) (41)|
|Low volume||3756||8.2||Not reported||1.8||1.9|
|Medium volume||10,419||2.9||Not reported||0.9||1.4|
|High volume||3242||5.3||Not reported||0.4||1.4|
|Sweden (2000 to 2003) (19)|
|Surgery on-site||25,525||9.7||Not reported||0.2||2.2|
|NCDR (2004 to 2006) (35)|
|Tasmania (2005 to 2007) (20)||1348||18.4||98||0.1||0.8*|
|CPORT-E (2006 to 2011) (23)|
|MASS COMM (2006 to 2011) (24)|
*In-hospital mortality; †Six-week mortality. CABG Coronary artery bypass grafting; CPORT-E Cardiovascular Patient Outcomes Research Team; MASS COMM Percutaneous Coronary Intervention (PCI) Outcomes in Community Versus Tertiary Settings; NCDR National Cardiovascular Data Registry
Table 2: Royal Alexandra Hospital (RAH, Edmonton, Alberta) percutaneous coronary intervention (PCI) results compared with benchmarks reported in the literature
In the past 10 years, percutaneous coronary revascularization has grown significantly in developed countries, while CABG surgery rates have remained static or declined. A 2010 report from the British Heart Foundation website  showed that PCI volumes in the UK increased by 350% from 1997 to 2008, whereas CABG rates peaked in 1997 and showed a flat to slight downward trend over the same period. Data from the United States showed that CABG rates declined 38% from 2001 to 2008 . A 50% decrease in CABG rate was also observed in Alberta from 2003 to 2010 .
In Canada, because of increasing demand for PCI services, a standalone PCI program was established as a pilot project by the Ontario provincial government at the Rouge Valley Hospital System in the Greater Toronto (Ontario) area in 2002. The program was closely monitored, and extensive procedural and outcome data collected. An expert panel report in 2004  recommended continued government support of the program. Since then, five new standalone PCI programs have been established in Ontario: in Windsor and Thunder Bay in 2007, in Brampton and Peterborough in 2012, and in Niagara in 2014.
Despite these developments, with its vast land mass and significant distances between major cardiac centres in Canada, a recent study explored Canadian population access to primary PCI and found that only a small proportion of the country’s geographical area was within 60 min of a PCI facility . Strategic placement of new PCI programs may improve such access.
In developing countries, as the incidence of coronary disease rise and new PCI centres are established, it does not appear logical nor cost effective to establish new cardiac surgery programs just to provide backup for the very rare instance that urgent CABG is required for PCI failure. However, a robust, fail-safe protocol for rapid transfer of patients to backup surgical centres needs to be firmly established and tested. Regular case conference between interventional cardiologists and cardiovascular surgeons is invaluable not only for peer review, but also in developing the collegiality and trust that facilitate timely decisions and cooperation in emergency cases. Regulatory and professional organization guidelines for operator/institutional PCI volumes and quality assurance should be applied to all programs irrespective of the presence or absence of on-site cardiac surgery.
For years, the presence of on-site cardiac surgery has provided comfort to the cardiology community as a safety net for PCI programs. Institutions with cardiac surgery programs are often tertiary referral centres with high volume catheter laboratories and experienced staff. Our 30-year experience showed that even without on-site cardiac surgery, a high-volume standalone PCI centre can achieve excellent outcomes comparable with major centres in the world. The presence of on-site cardiac surgery is perhaps just a surrogate for an experienced high-volume PCI centre. Current trends suggest that future needs in coronary revascularization in the 21st century in both developed as well as developing countries will in large part be fulfilled by standalone PCI centres.
This study is supported by a research grant from the Royal Alexandra Hospital Foundation.
The authors have no additional financial disclosures or conflicts of interest to declare.
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